I studied psychology at the University of Frankfurt and conducted my diploma thesis at the Max Planck Institute of Brain Research in the department of Neurophysiology, studying basic visual perception in humans. Later on I became interested in circuit neurophysiology employing rodent models.
Neuroscientists are faced with ever-changing patterns of activity as the state of the brain constantly varies on slow and rapid timescales. Those alternating states of neuronal excitability are associated with prominent changes in global brain activity, between sleep and wakefulness or from inattentive to vigilant states. Detailed observation of state fluctuations can significantly account for neural response variability, and allow for a more accurate exploration of the mechanisms of sensory coding.
We investigate the effect of different anesthesia-induced brain states on spontaneous and sensory evoked population activity by using optic-fiber based calcium recordings alongside BOLD fMRI measurements and by employing simultaneous multi-fiber recordings in different brain areas of anesthetized versus awake animals.
Institute for Clinical Radiology, Translational Research Imaging Center, University of Münster, Germany; Seattle Children’s Research Institute and Department of Biology, University of Washington, USA; Laboratorio de Neurosistemas, Universidad de Chile, Santiago.